This paper takes "End-of-Life Competence" (the comprehensive ability to achieve an autonomous and dignified closure at life"s end) as its core starting point. It first clearly defines End-of-Life Competence, revealing its essence as an individual"s intrinsic capability and objective. It further proposes that the realization of End-of-Life Competence relies on the foundational role of "Mindful-living competence"(the wisdom of living cultivated throughout the entire life course). By analyzing the dialectical relationship between the two (Mindful-living competence as the root, End-of-Life Competence as the fruit), the paper constructs the "Six-Capacity Model" of Mindful-living competence (Awareness Capacity, Letting-Go Capacity, Presence Capacity, Connection Capacity, Simplification Capacity, Legacy Capacity)and the "Triangular Support Model" of End-of-Life Competence(Intrapersonal Competence, Interpersonal Competence, Systemic Adaptability). Ultimately, it integrates and proposes the conceptual framework of" Lifelong Graceful End-of-Life Competence"(Lifelong Graceful End-of-Life Competence=Mindful-living competence + End-of-Life Competence), revealing its core value in enhancing life quality through reshaping the life-death perspective. At the practical level, it proposes a stepwise training path and a social support system, providing a theoretical paradigm for shifting palliative care from "end-of-life intervention" to "whole-life empowerment," and offering new paradigms for advancing palliative care practice, reconstructing life education systems, and formulating public health policies.